![]() ![]() Isotretinoin has at least five biologically important metabolites: 13- cis-4- oxo-retinoic acid (4- oxo-isotretinoin), all- trans-RA (tretinoin), all- trans-4- oxo-retinoic acid (4- oxo-tretinoin), 9- cisretinoic acid and 9- cis-4- oxo-retinoic acid. Unlike tretinoin (all-trans retinoic acid), isotretinoin has little or no ability to bind to cellular retinol-binding proteins or retinoic acid nuclear receptors (RARs and RXRs) but may act as a pro-drug that is converted intracellularly to metabolites that are agonists for RAR and RXR nuclear receptors. A dose of 0.5–1.0 mg/kg/day dramatically reduces sebum excretion by the order of 90% within 6 weeks. acnes and has anti-inflammatory properties. ![]() 1 – 7 It results in a significant reduction in sebum production, influences comedogenesis, lowers surface and ductal P. It achieves this remarkable efficacy by influencing cell-cycle progression, cellular differentiation, cell survival and apoptosis. Isotretinoin is the only therapy that impacts on all of the major aetiological factors implicated in acne. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |